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resource source identifier antibodies coup tfi interacting protein 2 ctip2  (Proteintech)
93
Proteintech resource source identifier antibodies coup tfi interacting protein 2 ctip2
Figure 4. Identified Layer III Neuron Exhibiting Elevated Spiking Activity during the Delay Period of the Working Memory Task and Its Distinct Rate Adaptation during Cognitive Flexibility (A) Reconstruction of the identified delay-elevated pyramidal neuron, TO34, located in layer III of the prelimbic cortex (section thickness: 50 mm, 5 sections) (blue, basal dendrites; red, apical dendrite; and green, main axon). Red dot indicates the position of the cell body (D, dorsal; M, medial; and L, lateral). (B) Position of the labeled cell body (shown with a red dot) in the tissue section (D, dorsal; L, lateral; M, medial). (C) Left: raster plot of the delay-elevated cell, TO34, across all trials during working memory and cognitive flexibility. Right: trial identifier as in Figure 3D. (D) Identified cell, TO34, showed ramping neuronal activity during the delay period of the working memory task (rule 1). Horizontal bars with asterisks indicate significance in firing rate change (*adjusted alpha = 0.0096, significance thresholds were calculated using a shuffling procedure on all correct trials; FDR for multiple comparison; see STAR Methods for details). Bottom: firing activity during delay is stimulus specific (chocolate versus cherry trials) during the working memory paradigm (rule 1) (Nchocolate = 9, Ncherry = 14 trials; *adjusted alpha = 0.0093, permutation test on all correct trials with two conditions; FDR correction; see STAR Methods for details). Dark lines, mean firing rate; shading, mean ± SEM. (E) Delay-elevated cell, TO34, exhibited significant decrease in firing rate upon rule change (Nrule 1 = 24, Nnaive = 23, and Nlearned = 10 trials; p = 0.0126, Kruskal- Wallis test, post hoc Dunn’s multiple comparisons test). Error bars denote ± SEM. **p < 0.01. (F) Delay firing activity of cell TO34 during rule 2 across correct non-conflicting trials, and correct or incorrect conflicting trials (Nnon-conf. correct = 15, Nconf. error = 11, and Nconf. correct = 6 trials; p = 0.0337, Kruskal-Wallis test, n.s. in post hoc Dunn’s multiple comparisons test). Error bars denote ± SEM. (G) Neurobiotin-labeled delay-elevated cell, TO34 (green, soma), was BRN1+ (arrowhead, nucleus; cyan), SATB2+ (arrowhead, nucleus; magenta), and <t>CTIP2+</t>
Resource Source Identifier Antibodies Coup Tfi Interacting Protein 2 Ctip2, supplied by Proteintech, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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pmk myd88 gfp hdrtemp deliz aguirre et  (Addgene inc)
90
Addgene inc pmk myd88 gfp hdrtemp deliz aguirre et
Figure 4. Identified Layer III Neuron Exhibiting Elevated Spiking Activity during the Delay Period of the Working Memory Task and Its Distinct Rate Adaptation during Cognitive Flexibility (A) Reconstruction of the identified delay-elevated pyramidal neuron, TO34, located in layer III of the prelimbic cortex (section thickness: 50 mm, 5 sections) (blue, basal dendrites; red, apical dendrite; and green, main axon). Red dot indicates the position of the cell body (D, dorsal; M, medial; and L, lateral). (B) Position of the labeled cell body (shown with a red dot) in the tissue section (D, dorsal; L, lateral; M, medial). (C) Left: raster plot of the delay-elevated cell, TO34, across all trials during working memory and cognitive flexibility. Right: trial identifier as in Figure 3D. (D) Identified cell, TO34, showed ramping neuronal activity during the delay period of the working memory task (rule 1). Horizontal bars with asterisks indicate significance in firing rate change (*adjusted alpha = 0.0096, significance thresholds were calculated using a shuffling procedure on all correct trials; FDR for multiple comparison; see STAR Methods for details). Bottom: firing activity during delay is stimulus specific (chocolate versus cherry trials) during the working memory paradigm (rule 1) (Nchocolate = 9, Ncherry = 14 trials; *adjusted alpha = 0.0093, permutation test on all correct trials with two conditions; FDR correction; see STAR Methods for details). Dark lines, mean firing rate; shading, mean ± SEM. (E) Delay-elevated cell, TO34, exhibited significant decrease in firing rate upon rule change (Nrule 1 = 24, Nnaive = 23, and Nlearned = 10 trials; p = 0.0126, Kruskal- Wallis test, post hoc Dunn’s multiple comparisons test). Error bars denote ± SEM. **p < 0.01. (F) Delay firing activity of cell TO34 during rule 2 across correct non-conflicting trials, and correct or incorrect conflicting trials (Nnon-conf. correct = 15, Nconf. error = 11, and Nconf. correct = 6 trials; p = 0.0337, Kruskal-Wallis test, n.s. in post hoc Dunn’s multiple comparisons test). Error bars denote ± SEM. (G) Neurobiotin-labeled delay-elevated cell, TO34 (green, soma), was BRN1+ (arrowhead, nucleus; cyan), SATB2+ (arrowhead, nucleus; magenta), and <t>CTIP2+</t>
Pmk Myd88 Gfp Hdrtemp Deliz Aguirre Et, supplied by Addgene inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/pmk myd88 gfp hdrtemp deliz aguirre et/product/Addgene inc
Average 90 stars, based on 1 article reviews
pmk myd88 gfp hdrtemp deliz aguirre et - by Bioz Stars, 2026-05
90/100 stars
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Image Search Results


Figure 4. Identified Layer III Neuron Exhibiting Elevated Spiking Activity during the Delay Period of the Working Memory Task and Its Distinct Rate Adaptation during Cognitive Flexibility (A) Reconstruction of the identified delay-elevated pyramidal neuron, TO34, located in layer III of the prelimbic cortex (section thickness: 50 mm, 5 sections) (blue, basal dendrites; red, apical dendrite; and green, main axon). Red dot indicates the position of the cell body (D, dorsal; M, medial; and L, lateral). (B) Position of the labeled cell body (shown with a red dot) in the tissue section (D, dorsal; L, lateral; M, medial). (C) Left: raster plot of the delay-elevated cell, TO34, across all trials during working memory and cognitive flexibility. Right: trial identifier as in Figure 3D. (D) Identified cell, TO34, showed ramping neuronal activity during the delay period of the working memory task (rule 1). Horizontal bars with asterisks indicate significance in firing rate change (*adjusted alpha = 0.0096, significance thresholds were calculated using a shuffling procedure on all correct trials; FDR for multiple comparison; see STAR Methods for details). Bottom: firing activity during delay is stimulus specific (chocolate versus cherry trials) during the working memory paradigm (rule 1) (Nchocolate = 9, Ncherry = 14 trials; *adjusted alpha = 0.0093, permutation test on all correct trials with two conditions; FDR correction; see STAR Methods for details). Dark lines, mean firing rate; shading, mean ± SEM. (E) Delay-elevated cell, TO34, exhibited significant decrease in firing rate upon rule change (Nrule 1 = 24, Nnaive = 23, and Nlearned = 10 trials; p = 0.0126, Kruskal- Wallis test, post hoc Dunn’s multiple comparisons test). Error bars denote ± SEM. **p < 0.01. (F) Delay firing activity of cell TO34 during rule 2 across correct non-conflicting trials, and correct or incorrect conflicting trials (Nnon-conf. correct = 15, Nconf. error = 11, and Nconf. correct = 6 trials; p = 0.0337, Kruskal-Wallis test, n.s. in post hoc Dunn’s multiple comparisons test). Error bars denote ± SEM. (G) Neurobiotin-labeled delay-elevated cell, TO34 (green, soma), was BRN1+ (arrowhead, nucleus; cyan), SATB2+ (arrowhead, nucleus; magenta), and CTIP2+

Journal: Cell reports

Article Title: Unexpected Rule-Changes in a Working Memory Task Shape the Firing of Histologically Identified Delay-Tuned Neurons in the Prefrontal Cortex.

doi: 10.1016/j.celrep.2019.12.102

Figure Lengend Snippet: Figure 4. Identified Layer III Neuron Exhibiting Elevated Spiking Activity during the Delay Period of the Working Memory Task and Its Distinct Rate Adaptation during Cognitive Flexibility (A) Reconstruction of the identified delay-elevated pyramidal neuron, TO34, located in layer III of the prelimbic cortex (section thickness: 50 mm, 5 sections) (blue, basal dendrites; red, apical dendrite; and green, main axon). Red dot indicates the position of the cell body (D, dorsal; M, medial; and L, lateral). (B) Position of the labeled cell body (shown with a red dot) in the tissue section (D, dorsal; L, lateral; M, medial). (C) Left: raster plot of the delay-elevated cell, TO34, across all trials during working memory and cognitive flexibility. Right: trial identifier as in Figure 3D. (D) Identified cell, TO34, showed ramping neuronal activity during the delay period of the working memory task (rule 1). Horizontal bars with asterisks indicate significance in firing rate change (*adjusted alpha = 0.0096, significance thresholds were calculated using a shuffling procedure on all correct trials; FDR for multiple comparison; see STAR Methods for details). Bottom: firing activity during delay is stimulus specific (chocolate versus cherry trials) during the working memory paradigm (rule 1) (Nchocolate = 9, Ncherry = 14 trials; *adjusted alpha = 0.0093, permutation test on all correct trials with two conditions; FDR correction; see STAR Methods for details). Dark lines, mean firing rate; shading, mean ± SEM. (E) Delay-elevated cell, TO34, exhibited significant decrease in firing rate upon rule change (Nrule 1 = 24, Nnaive = 23, and Nlearned = 10 trials; p = 0.0126, Kruskal- Wallis test, post hoc Dunn’s multiple comparisons test). Error bars denote ± SEM. **p < 0.01. (F) Delay firing activity of cell TO34 during rule 2 across correct non-conflicting trials, and correct or incorrect conflicting trials (Nnon-conf. correct = 15, Nconf. error = 11, and Nconf. correct = 6 trials; p = 0.0337, Kruskal-Wallis test, n.s. in post hoc Dunn’s multiple comparisons test). Error bars denote ± SEM. (G) Neurobiotin-labeled delay-elevated cell, TO34 (green, soma), was BRN1+ (arrowhead, nucleus; cyan), SATB2+ (arrowhead, nucleus; magenta), and CTIP2+

Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER Antibodies Coup-TFI interacting protein 2 (CTIP2) [host Rb; Dil 1:1000] Abcam Cat# ab28448; RRID: AB_1140055 Wolfram syndrome-1 (WFS1) [host rb; Dil 1:1500] Proteintech Cat# 11558-1; RRID: AB_2216046 BRN1 [host gt; Dil 1:500] Santa Cruz Cat# sc6028, gift from Tibor Harkany, used in Keays et al. (2007) SATB2 [host m; Dil 1:100] Abcam Cat# ab51502; RRID: AB_882455 Chemicals, Peptides, and Recombinant Proteins Neurobiotin Tracer Vector Laboratories Cat# SP-1120; RRID: AB_2313575 Critical Commercial Assays Vectastain ABC kit Vector Laboratories Cat# PK6100; RRID: AB_2336819 VECTASHIELD Antifade Mounting Medium Vector Laboratories Cat# H-1000; RRID: AB_2336789 Experimental Models: Organisms/Strains Long-Evans rats Charles River Laboratories https://www.criver.com/ Software and Algorithms MATLAB R2012b Mathworks https://www.mathworks.com/products/ matlab.html Prism 7 GraphPad https://www.graphpad.com/ Spike2 7.11 Cambridge Electronic Design Limited (CED) http://ced.co.uk/ Klustakwik Harris et al., 2000 http://klustakwik.sourceforge.net/ klusta and KlustaViewA Rossant et al., 2016 https://klusta.readthedocs.io/en/latest/ Zen Zeiss https://www.zeiss.co.uk/corporate/home.html Imaris 9.2 BitPlane, Oxford Instruments https://imaris.oxinst.com/ ImageJ 1.47v ImageJ https://imagej.nih.gov/ij/ Other Silicon Probe; Buzsaki64-H64_30mm NeuroNexus https://neuronexus.com/

Techniques: Activity Assay, Labeling, Comparison, Chocolate